ea0025oc2.4 | Steroids | SFEBES2011
Wood Stacy
, Ejaz Ayesha
, Livie Craig
, MacKenzie Scott
, Connell John
, Davies Eleanor
Essential hypertension is known to have a large genetic component. Variation in the CYP11B2 gene, which encodes the aldosterone synthase enzyme, is associated with excess aldosterone production and hypertension but the causative mechanism remains elusive. miRNAs are a class of post-transcriptional regulatory molecules, implicated in cardiovascular disease, development and tumourogenesis. They act by targeting the 3′ untranslated region (UTR) of mRNAs, inhibiting t...